Several subunits of the SWI/SNF complex including SNF5 (SMARCB1/INI1/BAF47), ARID1A (BAF240A), SMARCA4 (BRG1), ARID1B (BAF250B), ARID2 (BAF200) and PBRM1 (BAF180) exert critical tumor suppression activities, through inhibiting oncogenic transcription, cell cycle, epigenetic instability and etc. [32]. The gene discussed is PBRM1; the disease is neoplasm.