A study on NSCLC tumor and the lung cancer cell line found that histone H3 lysine 36 (H3K36) demethylase KDM2A (FBXL11 and JHDM1A) activates ERK1/2 by the epigenetic regulation of DUSP3 [70]. This evidence concerns the gene DUSP3 and non-small cell lung carcinoma.