MAPK3 and non-small cell lung carcinoma: Furthermore, overexpression of KDM2A in low KDM2A NSCLC cell line increased cell proliferation and invasion capabilities, and increased ERK1/2 through a decrease in the dual-specificity phosphatase-3 (DUSP3) gene by demethylating H3K36me2 at the DUSP2 promotor [70].