Amyloid β is known to induce the astrogliosis and glial fibrillary acidic protein (GFAP) overexpression typical of AD by an interaction with beta1-integrin which leads to PKC-mediated activation of Nox2 NADPH oxidase; inhibitors of NADPH oxidase prevent this astrogliosis and GFAP induction [135]. This evidence concerns the gene CYBB and Alzheimer disease.