CDKN1A and B-cell chronic lymphocytic leukemia: Furthermore, several other miRNAs have been found to be deregulated in CLL: miR-192 is down-regulated and the direct target CDKN1A/p21 is up-regulated in CLL cells [26]; miR-155 enhances responsiveness to B-cell receptor (BCR) ligation in CLL [27]; miR-338-3p and miR-181b in a cohort of CLL samples inversely correlated with USP7, a de-ubiquitinase inactivating tumor suppressor like P53, PTEN, and FOXO [28].