Increased expression of COX-2 and LOX [29,33,35,89] is observed during tumor growth, and a number of compounds of the arachidonic acid cascade, including prostaglandin E2 and leukotrienes, support the survival and proliferative activity of tumor cells, promote tumor growth, accelerate tumor angiogenesis and suppress antitumor immunity. The gene discussed is LOX; the disease is neoplasm.