The major findings of this study are the following: (1) B7-H3 is expressed mainly within the tumour stroma; (2) B7-H3 expression correlates significantly with tumour location, Lauren phenotype, and pT category; (3) median density of CD8+ T cells differs significantly between TC and IF; (4) in cases with higher stromal B7-H3 expression, restricted CD8+ cell infiltration in the TC was observed. Here, CD276 is linked to neoplasm.