IGHE and food allergy: Our study provides a better understanding of the gut microbiome with respect to the presence of Ruminococcaceae UCG-002 interacting with other dominant taxa including Eubacterium oxidoreducens group, Eubacterium coprostanoligenes group, Lachnospiraceae (NK4A136 and UCG-008), Bacteroides, Alistipes, Parabacteroides, Prevotella 2 as well as Rhodospirillaceae in the pathogenesis of IgE-mediated food allergy and these microbial taxa were mainly involved in methane metabolism and glycerolipid metabolism.