Transduction of CD34+ human hematopoietic stem cells (HSCs) with a chimeric rh/huTRIM5α, in combination with a CCR5 short hairpin RNA (shRNA) and a TAR decoy, was shown to be effective in protecting against HIV-1 challenge and providing a selective survival advantage in human CD4+ T cells upon infection in a humanized mouse model [217]. Here, CD4 is linked to infection.