CD4 and HIV-1 infection: The demonstrated functionalities of huTRIM5α to prevent LINE-1 retrotransposition, restrict HIV-1 in primary human LCs and in DCs treated with SUMOylation inhibitor, and mediate immunoproteasome-dependent restriction of HIV-1 in CD4+ T cells underpin the intrinsic ability of the human huTRIM5α orthologue to restrict HIV-1 infection [62,64,65,186].