In the conditional mouse model Pdf1a-Cre, Brg1 loss in acinar cells cooperates with KrasG12D at early stages to form cystic neoplastic lesions similar to intraductal papillary mucinous neoplasia (IPMN), which progresses to a less aggressive form of PDA without mPanINs [56] due to the role of Brg1 in “acinar to ductal dedifferentiation” [57]. This evidence concerns the gene SMARCA4 and pancreatic intraductal papillary-mucinous neoplasm.