PARP6 and Patent ductus arteriosus: In a recent study published by The Cancer Genome Atlas (TCGA) on 150 cases of PDA, the integration of DNA methylation and mRNA expression showed 98 genes silenced by methylation, some of them previously involved in other tumor types but not described in PDA, such as ZFP82, PARP6 and DNALC15, which were identified in breast cancer as chemo-resistance associated genes [13].