PRKN and Parkinson disease: The human genome encodes approximately 14 RBR-type E3 ligases, including HOIL-1L interacting protein (HOIP), PRRKIN (the product of the PARK2 gene mutated in Parkinson’s disease), the central E3 subunit of the linear ubiquitin chain assembly complex (LUBAC), two RING fingers and DRIL 1 (TRAID1), and human homologue of Ariadne (HHARI), all of which are highly conserved from yeast to humans [72,73,74,75,76].