Taken together, these results suggest that fargesin induced complex formation of p21WAF1/Cip1/CDK2/cyclin E, resulting in impairment of the G1/S cell cycle transition and inhibition of cell proliferation of premalignant JB6 Cl41 and HaCaT cells, as well as WiDr, HCT8, and HCT116 colon cancer cells. The gene discussed is CDK2; the disease is colonic neoplasm.