Taken together, these results suggest that fargesin induced complex formation of p21WAF1/Cip1/CDK2/cyclin E, resulting in impairment of the G1/S cell cycle transition and inhibition of cell proliferation of premalignant JB6 Cl41 and HaCaT cells, as well as WiDr, HCT8, and HCT116 colon cancer cells. This evidence concerns the gene CDK2 and malignant colon neoplasm.