BDNF and Anxiety: Therefore, we examined whether chronic treatment with AdipoRon can affect hippocampal-dependent spatial memory and anxiety-like behavior, as well as hippocampal neurogenesis in a dose-dependent manner, and whether AdipoRon treatment modulates blood levels of neurogenesis-related factors, including brain-derived neurotrophic factor (BDNF), adiponectin, and corticosterone.