Hippocampi and amygdalae from 3x Tg-AD linalool-treated mice also showed a large reduction in extracellular β-amyloidosis, tauopathy, astrogliosis, and microgliosis, as well as pro-inflammatory marker levels of p38 MAPK, NOS2, COX2 and IL-1β. Here, PTGS2 is linked to Alzheimer disease.