There were no differences in expression of TLR4(1) in IGHV UM CLL cases compared to IGHV MUT (0.124 in vs. 0.141, p = 0.1316) in PBMC as well as in BMMC (0.1265 vs. 0.131, p = 0.493). This evidence concerns the gene TLR4 and B-cell chronic lymphocytic leukemia.