TLR2 and B-cell chronic lymphocytic leukemia: We found that the expression of TLR2 in BMMC was significantly higher in CLL patients with the unmutated status of the immunoglobulin heavy chain variable (UM IGHV) genes than in patients with IGHV mutation (MUT) with a median 0.212 vs. 0.1795 (p = 0.0181), respectively (Figure 3A).