Similarly, the expression of splicing variants of TLR(4), including TLR4(1) and TLR4(4), was significantly lower in CLL patients than in HVs (median of TLR4(1): 0.1330 vs. 0.1970, p < 0.0001 and median of TLR4(4): 0.1840 vs. 0.2066, p = 0.0353) (Figure 2A,C). This evidence concerns the gene TLR4 and B-cell chronic lymphocytic leukemia.