ESR1 and neoplasm: We investigated the relationship of MDM2 and MDM4 polymorphisms genotype with the clinicopathological features, including the patient’s age at diagnosis, pathological tumor size (pT), pathological lymph node involvement (N), status of estrogen (ER), progesterone (PR) receptors and human epidermal growth factor receptor 2 (HER2), tumor grade (G1 and G2, G3), progress, metastasis, and death.