Given that tumour infiltrating immune cells are found in tumours with high mutational burden, the expression of immunogenic epitopes on tumour epithelial cells accounts for a strong TH1 immune response, formation of tertiary lymphoid structures, and the activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT)-dependent immune signalling pathways [19,20,23]. This evidence concerns the gene SOAT1 and neoplasm.