Akin to the pro-tumourigenic signalling pathways that regulate primary colorectal cancer progression, within metastatic lesions, the activation of Wnt, TGF-β, BMP, NOTCH, and STAT3 signalling pathways, as well as cellular metabolic and cell survival pathways including PI3K/AKT and MAPK, drive metastatic outgrowth. This evidence concerns the gene TGFB1 and colorectal cancer.