The CMS2 subtype represents 37% of early-stage tumours, characterised by the upregulation of WNT and MYC downstream target gene signatures, higher expression of EGFR, ERBB2 (HER2), insulin-like growth factor 2 (IGF2), insulin receptor substrate 2 (IRS2), and transcription factor hepatocyte nuclear factor 4α (HNF4A) [19]. This evidence concerns the gene IRS2 and neoplasm.