Additionally, the prognostic role of tumour immunoscores (CD3, CD8, granzyme B, or FOXP3+ immune cells) in metastatic colorectal cancer lesions at the invasive margin of liver metastases correlated positively to chemotherapy responses with 100% specificity, with high immune infiltrates correlating with longer progression-free survival in patients who received chemotherapy [27]. This evidence concerns the gene GZMB and neoplasm.