However, Chidlow et al. [34], in an experimental glaucoma model by laser photocoagulation of the trabecular meshwork in rats, did not find TNF-α and IL-1β immunolabeling in either the retina or the optic nerve, despite evidence of moderate IL-1β and TNF-α mRNA upregulation in response to elevated IOP. Here, IL1B is linked to glaucoma.