BRCA1 and Fanconi anemia: Almost half of HGSOC tumors are characterized by homologous recombination (HR) deficiency through germline or somatic mutations in BRCA1/2 (20%), BRCA1 hypermethylation (11%), and/or dysregulation of other HR genes including PTEN, ATM or ATR, RAD51C, EMSY and Fanconi anemia genes [3].