BRCA1 and ovarian neoplasm: Although BRCA-mutated breast and ovarian tumors are often highly aggressive, a number of studies suggest that these patients may achieve a slightly better short-term therapeutic response (2–3 year overall survival) compared to patients with wild-type BRCA1 or BRACA2, as these tumors may be more responsive to DNA-damaging drugs; however, long-term survival and/or progression-free survival differences remain unclear [65,79,80,81,82].