For ovarian cancer patients, these biomarkers include single gene markers CEA (Carcinoembryonic Antigen), CA125 (Cancer Antigen 125), and HE4 (Human Epididymis protein 4), as well as multivariate index assays including OVA1, ROMA, and OVERA [250,251,252,253,254,255,256,257]. This evidence concerns the gene MUC16 and ovarian cancer.