UBB and neoplasm: Likewise, ubiquitin B (UBB) and ubiquitin C (UBC) were identified as a paralog deficiency dependency in ovarian cancers, implying the essentiality of UBC in cell lines with repressed UBB [166]; shRNA mediated silencing of UBC in UBB repressed ovarian cancer xenograft model lead to tumor regression and prolonged survival [160].