PRKN and diabetic cardiomyopathy: Overexpression of Sirt3 activated Fjxo3A deacetylation and Parkin expression, stimulated Parkin-dependent mitophagy, suppressed apoptosis and mitochondrial damage in cardiomyocytes, and also crucially influenced the diabetic cardiomyopathy initiation and development in a mouse model of diabetic cardiomyopathy [39].