Activation of ALDH2 inhibits phosphatase and PINK1/Parkin expression both in ischemia/reperfusion rats and hypoxia/reoxygenation H9C2 cells, protecting the heart against ischemia/reperfusion injury via regulating mitophagy, preventing 4-hydroxynonenal, ROS, and mitochondrial superoxide accumulation [100]. The gene discussed is PRKN; the disease is ischemia.