IGFBP3 and pseudoxanthoma elasticum (inherited or acquired): However, this only reached statistical significance in the case of IGFBP3 gene expression in AT-treated PXE fibroblasts compared to DMSO-treated PXE fibroblasts (PXE DMSO: 0.22 ± 0.05; PXE AT: 0.38 ± 0.08).