In the case of IGFBP3, we could observe a reduction of gene expression as well as protein concentration for DMSO-treated PXE fibroblasts compared to DMSO-treated NHDFs, which confirms our previous results [17], indicating a potential dysregulation of IGF1 signaling in peripheral tissues of PXE patients. The gene discussed is IGFBP3; the disease is pseudoxanthoma elasticum (inherited or acquired).