Compared to the DMSO-treated NHDFs, IL6 gene expression in AT-treated PXE fibroblasts was significantly increased (control DMSO: 1.71 ± 0.11; PXE AT: 3.89 ± 0.40), whereas IL6 protein concentration in cell culture supernatants of AT-treated PXE fibroblasts showed no differences compared to DMSO-treated NHDFs. The gene discussed is IL6; the disease is pseudoxanthoma elasticum (inherited or acquired).