A large Mendelian randomization study had already linked Interleukin-6 Receptor (IL6-R) signaling to CAD risk [46], when the large 2013 GWAS by the CARDIoGRAMplusC4D consortium discovered that a risk variant in the IL6R gene was significantly associated with CAD shortly after [21]. Here, IL6R is linked to coronary artery disorder.