Another gene relevant for endothelial function is JCAD, also referred to as KIAA1462. This gene was found to be genome-wide significantly associated with CAD in the GWAS approaches of the Coronary Artery Disease C4D Genetics Consortium and Erdmann et al. in 2011 [40,41], and subsequent experimental studies have uncovered the function of its encoded protein Junctional Cadherin 5 Associated (JCAD) [39,87]. This evidence concerns the gene JCAD and coronary artery disorder.