Nevertheless, similar to the effect of the human risk allele, Sh2b3/Lnk knockout in mice was associated with reduced thrombus stability and enhanced arterial thrombosis [78], but also promoted atherosclerosis in mice with hematopoietic Sh2b3/Lnk deficiency and hypercholesterolemia [79]. This evidence concerns the gene SH2B3 and Hypercholesterolemia.