IFNA1 and systemic lupus erythematosus: The importance of these nucleic acid degrading enzymes is perhaps best illustrated by their loss-of-function mutations [151] in Aicardi–Goutières syndrome (AGS) a devastating disease characterized by constitutively high production of type I IFNs, neurologic deficits due to IFN toxicity, and autoimmunity with all the hallmarks and autoantibodies of SLE [152].