IFNA1 and systemic lupus erythematosus: While this second pathway is not restricted to L1 transcripts, either, or both, of these mechanisms can explain the elevated expression of IFN-inducible genes, referred to as the “IFN signature” [116,123] in SLE and related autoimmune diseases, such as idiopathic inflammatory myopathies and primary Sjögren’s syndrome [124].