Aberrant miR-29 isoform expression is involved in the development of cardiac fibrosis and congestive heart failure whereas a protective function of miR-29a-3p in endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy via inhibiting NFATc4 expression has been reported by Li M et al. [45]. The gene discussed is EDN1; the disease is congestive heart failure.