RASA2 and hypertrophy: They also demonstrated that miR-1 regulates cardiac hypertrophy by negatively regulating the expression of the hypertrophy-associated genes, such as Acta1, Myh7 and Nppa, calmodulin, Mef2a, Ras GTPase-activating protein (RasGAP) and cyclin-dependent kinase 9.