Furthermore, 129.Smad3−/− mice exhibited a significantly lower GN score (1.33 ± 0.87) as well as dramatically reduced crescent formation (0.22 ± 0.44) than that of WT mice (2.89 ± 0.96; 1.44 ± 1.33, respectively, p < 0.05, Figure 5C). The gene discussed is SMAD3; the disease is ganglioneuroma.