Tumor HMGB1 and TLR4/RAGE receptors promote cell proliferation, survival, migration, epithelial-to-mesenchymal transition, and apoptosis resistance involving interaction with β-catenin, Runx2, YAP1, and TGF-β1/Smad [38,42,43,44,45,46]. This evidence concerns the gene HMGB1 and neoplasm.