The cancer cell survival suppressive effect of dipyridamole was paralleled by a reduction of the HMGB1/RAGE axis, and proliferation- and migration-related β-catenin, YAP1, Runx2, TGFβ1/Smad, and cyclin D1 in in vitro and in vivo tumor growth models. Here, TGFB1 is linked to neoplasm.