Cytokines, chemokines, thrombin, ADP, serotonin, thromboxane A2, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and TGF-β1 are ubiquitous components of platelets and have been implicated in cancer malignancy and inflammation. The gene discussed is TGFB1; the disease is cancer.