However, this has complicated the pathologic diagnosis of HGBL since the morphologic criteria of “features intermediate between DLBCL and BL” is very arbitrary and can be interpreted subjectively by individuals, and the definition of “Near-100% Ki-67 labeling index”, characteristic for BL, has not been clearly determined yet [1,3,16]. This evidence concerns the gene MKI67 and high grade B-cell lymphoma.