Furthermore, resveratrol downregulates NF-KB phosphorylation and acetylation causing impairments in factors involved in tumor invasion and metastasis, and the physical interaction between NF-KB and SIRT1 indicates that NF-KB could be implicated in resveratrol/SIRT1-dependent anticancer activity in cancer cells [38,40,41]. The gene discussed is SIRT1; the disease is cancer.