As a consequence, in PCOS groups, the levels of glycodeoxycholic acid (GDCA) and tauroursodeoxycholic acid (TUDCA) decreased due to the action of the encoded protein, bile salt hydrolases: thus, an increased abundance of B.vulgatus reduced the concentrations of the bile acids, which negatively influenced the production of interleukin-Normally, IL-22 administration is very effective in ameliorating insulin resistance, regulating disrupted oestrous cycles, reversing ovary morphological changes and improving infertility, all typical aspect of PCOS phenotypes. Here, IL22 is linked to Insulin resistance.