IL22 and polycystic ovary syndrome: As a consequence, in PCOS groups, the levels of glycodeoxycholic acid (GDCA) and tauroursodeoxycholic acid (TUDCA) decreased due to the action of the encoded protein, bile salt hydrolases: thus, an increased abundance of B.vulgatus reduced the concentrations of the bile acids, which negatively influenced the production of interleukin-Normally, IL-22 administration is very effective in ameliorating insulin resistance, regulating disrupted oestrous cycles, reversing ovary morphological changes and improving infertility, all typical aspect of PCOS phenotypes.