Moreover, Qi et al. reported low levels of IL-22 in individuals with PCOS, mediated by reduced IL-22 secretion induced by glycodeoxycholic acid; indeed, reduced glycodeoxycholic acid and tauroursodeoxycholic acid levels were found after transplantation of fecal microbiota from women with PCOS to recipient mice, resulting in insulin resistance, altered bile acid metabolism, reduced interleukin-22 secretion, worst ovarian functions and infertility [31]. Here, IL22 is linked to Insulin resistance.