Examples of such syndromes are Ataxia telangiectasia, Fanconi anemia, Ligase IV syndrome, Radiosensitive severe combined immunodeficiency disease (RS-SCID), Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome, or ataxia telangiectasia and Rad3-related protein (ATR)-Seckel syndrome [15,97,98,99]. Here, ATR is linked to Ataxia-telangiectasia.