Another recognized competitive DUB capable of inducing apoptosis in MM cells is VLX1570, which is a more potent and soluble analogue of b-AP15 able to strongly inhibit Ubiquitin carboxyl-terminal hydrolase 14 (UPS14) activity, inducing the accumulation of polyubiquitin chains, the expression of the chaperone HSP70B’, the oxidative stress marker heme oxygenase 1 (Hmox-1), and apoptosis in MM cells. The gene discussed is USP14; the disease is Miyoshi myopathy.