PMAIP1 and small cell lung carcinoma: In this regard, by enhancing the Noxa-mediated activation of Bak, followed by an increase in the mitochondrial apoptotic pathway, the BH3-mimetic GX15-070 demonstrated synergic activity with bortezomib in mantle cell lymphoma, while ABT-737 induced apoptosis in small cell lung cancer via Noxa/Mcl1 [54,55].