CASP9 and Miyoshi myopathy: Combining BTZ with TAK-242 (Resatorvid), which is a selective TLR4 inhibitor, they overcame MM cell resistance, generating higher oxidative stress due to an ROS and reactive nitrogen species (RNS) increase, followed by depolarization of the mitochondrial membrane and cytochrome c release into the cytosol, finally resulting in the activation of caspase-9 [48].