HMOX1 and Miyoshi myopathy: Inducing oxidative stress in MM cells, b-AP15 revealed high antiproliferative activity, causing mitochondrial deformations, through the induction of the chaperones heat shock protein 70B’ (HSP70B’) and heat shock protein 40 (HSP40), resulting in nuclear factor erythroid 2-related factor 2 (Nrf-2) and its target heme-oxygenase 1 (HO-1) induction, but without lipid peroxidation [37].