None of the miRNA were differentially expressed upon dividing the newly diagnosed Stage IV CRC patients (surgery naïve and recurrent) into subgroups according to age groups (below and above 50 years), body mass index (underweight, normal, overweight, obese), smoking habits, alcohol intake, family history of cancer, tumor sidedness, and KRAS mutation (Data not shown). The gene discussed is KRAS; the disease is neoplasm.