In conclusion, the fraction Fa.EtAc having highest level of total phenolic/flavonoid contents resulted in good inhibition of AChE and BChE enzymes with low IC50 values that also exhibited highest % free radical scavenging potential against DPPH and ABTS could be used as alternative drug to treat oxidative stress and neurodegenerative diseases. This evidence concerns the gene BCHE and neurodegenerative disease.