APP is described in its Gene page at NCBI (https://www.ncbi.nlm.nih.gov/gene/351 (accessed on 10 December 2020)) as follows: “encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.” As indicated in the NCBI APP gene page, “some of the peptide products of APP cleavage are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. This evidence concerns the gene APBB1 and early-onset autosomal dominant Alzheimer disease.