APP and Alzheimer disease: APP is described in its Gene page at NCBI (https://www.ncbi.nlm.nih.gov/gene/351 (accessed on 10 December 2020)) as follows: “encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.” As indicated in the NCBI APP gene page, “some of the peptide products of APP cleavage are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease.