TWIST2 and synovial sarcoma: Expression profiling of normal and SS lymphoblasts with Exon array GeneChips revealed that out of the top 1223 differentially regulated genes, 1155 were down-regulated and only 70 were up-regulated, which is a higher proportion of genes (~17 times) that apparently are activated by TWIST2 than those estimated to be activated in skin fibroblasts of SS patients (Supplementary Table S2).