Hence the % of monoclonal Igs of unknown specificity was highest for RRMM patients (43/57 or 75.4%) compared to NDMM (44/90 or 48.9%, p = 0.0014) or both cohorts of MM compared to MGUS/SM (35/155 or 22.6%, p < 0.0001 vs. RRMM and p < 0.0001 vs. NDMM). Here, CUBN is linked to Miyoshi myopathy.