Cystic Fibrosis (CF) is an autosomal genetic disease caused by alterations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leading to a dysfunctional protein and usually characterized by lung disease, digestive symptoms due to pancreatic insufficiency, male infertility due to absence of vas deferens, and increased chloride loss by sweat [1]. This evidence concerns the gene CFTR and male infertility.