The adapter CAR-T (aCAR-T) is a new concept in which antigen recognition of CAR-T cells is split into multiple agents (e.g., CD32, CD33, CD38, CD123, CD135, CD305, and CLL1 for AML) by linker-label-epitopes (LLEs) that allows qualitative regulation of CAR-T function (for example, recognition of four or more antigens to activate and three or less not to do). The gene discussed is IL3RA; the disease is acute myeloid leukemia.