There is ample evidence showing that various apoptosis markers including phosphatidylserine (PS) exposure, depolarisation of the mitochondrial transmembrane potential, Bcl-2 family protein expression, activation of caspase-3 as well as of caspase-9 are significantly involved in platelet apoptosis in ITP [27,28]. The gene discussed is CASP3; the disease is autoimmune thrombocytopenic purpura.