H2AX and non-small cell lung carcinoma: H1975 NSCLC cells depleted of COMMD1 demonstrated increased activation of ATM (P-ATM 1981), however, reduced p53 S15 stabilization, reduced pChk2 T68 phosphorylation and reduced phosphorylation of H2AX (γ-H2AX), further showing defective DNA repair (Figure 1B and Figure S1B).