As knockdown of COMMD1 was previously shown to sensitize breast cancer cells to the DNA damaging agents, cisplatin and doxorubicin [38], COMMD4 depletion sensitizes NSCLC cells to irradiation [36] and COMMD1 functions in the repair of DSBs (Figure 1), we explored whether COMMD1-depleted NSCLC cells were hypersensitive to irradiation. Here, COMMD4 is linked to breast cancer.