MMP11 and neoplasm: Cox’s regression model demonstrated that tumor stage (Stage II: RR: 1.04 (CI: 0.6–1.9); stage III: 2.2 (1.1–4.6); p = 0.022), and tumor budding combined with MMP11 expression by MICs (low-grade/MMP11 +: 9.8 (3.3–28.8); high-grade/MMP11-: 5.9 (1.9–17.6); high-grade/MMP11 +: 20.8 (7.1–60.4) p < 0.0001) were independent prognostic factors.