MMP11 and breast carcinoma: Likewise, our group previously reported that tumors with MMP-11 expression by MICs showed a high cell immune ratio ((CD68+) macrophages/(CD3+) T cells + (CD20+) B cells) at the invasive front [49], an upregulation of inflammatory-related genes [50,51], and a poor prognosis in breast carcinomas [24,28].