Nevertheless, these initial mouse models paved the way for more sophisticated modeling systems, including chimeric Nf1−/− mice, some of which developed plexiform neurofibroma-like lesions, and Nf1+/− and Trp53+/− (NPcis) mice, which rapidly developed MPNST-like tumors [72,73]. Here, NF1 is linked to plexiform neurofibroma.