The last review discussing naturally occurring and genetically engineered animal models of neurofibromatosis was published by Riccardi, Womack, and Jacks in 1996, after the first transgenic mouse model of NF1 was developed and the first instance of a herd of dairy cattle with an apparently heritable form of neurofibromatosis was described [31]. The gene discussed is NF1; the disease is neurofibromatosis.