In acute myeloid leukemia (AML), human pancreatic cancer, and colorectal cancer cells, as well as in LSL-KrasG12D/+; Trp53flox/flox-driven lung and pancreatic tumors, 13C-labeled BCAAs contributed minimally to mitochondrial TCA cycle intermediates irrespective of which BCAT1/2 isoform is expressed in each context [180,187,188,189,190]. Here, BCAT1 is linked to pancreatic neoplasm.