Knockdown of S100A13 has been demonstrated to diminish the expression of high-mobility group A (HMGA)-1 as well as Snail, and increase the expression of E-cadherin in thyroid cells, indicating that S100A13 may potentially play an important role in the EMT of thyroid cancer cells and the disease progression [198]. Here, S100A13 is linked to thyroid gland carcinoma.