EPAS1 and neoplasm: Correspondingly, methylenetetrahydrofolate dehydrogenase 2 (MTHDF2), an enzyme that is important in one-carbon metabolism, is believed to regulate m6A deposition on HIF-2α in renal cell carcinoma (RCC), which leads to increased HIF-2α translation, metabolic reprogramming, and tumor progression [65,66].