PPARGC1A and clear cell renal carcinoma: Zhuang and colleagues identified that in clear cell renal carcinoma, FTO induces oxidative stress through m6A demethylation at the 3′UTR of PGC1α, a major regulator of mitochondrial metabolism, which resulted in increased PGC1α mRNA stability and translation and increased ROS production [27] (Figure 2D and Figure 3A, Table 1).