CXCL8 and cystic fibrosis: In a subsequent study, Zulueta et al. confirmed that MSCs-derived EVs were capable of partially restoring PPARγ signaling in CF bronchial epithelial cell lines, downregulating the transcription and expression of some pro-inflammatory cytokines (IL-1β, IL-8, IL-6), and partially impairing the nuclear translocation of NF-κB [73].