Accordingly, previous reports showed that imidazole-based H3R antagonists, including clobenpropit and ciproxifan, mitigated several oxidative stress markers (e.g., MDA and GSH) in amphetamine- or dizocilpine-augmented oxidative stress in a preclinical mouse model of schizophrenia, suggesting the protective effect of H3R antagonists in such disease conditions [87,88,89]. This evidence concerns the gene HRH3 and schizophrenia.