Beside this, CXCR4 is vital for normal lymphocyte homing and trafficking and is closely linked to the pathobiology of several lymphomas such as chronic lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), marginal zone lymphoma (MZL), hairy cell leukemia (HCL) and mantle cell lymphoma (MCL) [1,3,4,5,6,7,8]. This evidence concerns the gene CXCR4 and hairy cell leukemia.