ML is caused in many cases by FUS-DDIT3 and less commonly EWSR1-DDIT3 gene fusion [70,71,104], which is hypothesized to lead to a perturbation of PPARγ activity [105,106]; other forms of liposarcoma (pleomorphic sarcoma and the de-differentiated/well differentiated liposarcomas) have variable gene fusions that rarely involve EWSR1/FUS/TAF15 [107]. This evidence concerns the gene FUS and liposarcoma.