The greater need for ongoing surveillance for EWSR1-associated sarcomas lies with the more aggressive and malignant Ewing’s sarcoma (ES), desmoplastic small round cell tumour (DSRCT), clear cell sarcoma (CCS), myxoid liposarcoma (ML), and extra-skeletal myxoid chondrosarcoma (EMC) (Figure 2). The gene discussed is EWSR1; the disease is sarcoma.