In the present review we combined a bioinformatic approach with a literature review to define a miRNA profile (miR-15b-5p, miR-16-5p, miR-122-5p, miR-1260b, miR-149-3p, miR-193b-3p and miR-383-3p) that has the potential to target both LAT1 and ASCT2 in CRC. This evidence concerns the gene SLC7A5 and colorectal carcinoma.