Regarding their effects on CRC, the deregulation of miR-122-5p, miR-1273g-3p, miR-16-5p, miR-3199, miR-383-3p, miR-619-5p and miR-6883-5p was associated with the upregulation of important players of oncogenic pathways, such as TRIM29, CDC25A, PI3K/Akt, mTOR, VEGFA, MALAT1, SMAD4, STMN1, APRIL and CDK4, with an impact on cell proliferation, invasion and migration. The gene discussed is SMAD4; the disease is colorectal carcinoma.