In addition to that, the liver is recognized as the most common metastatic site of CRC and cumulative evidences show that LAT1 and ASCT2 are overexpressed in hepatocellular carcinoma (HCC) and that these cells present a 10–20 fold increase in glutamine uptake, compared to normal hepatocytes [27,38,99,100,101]. The gene discussed is SLC7A5; the disease is hepatocellular carcinoma.