Neo-angiogenesis also can be due to hyper-expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) largely found in endothelial cells treated with exosomes released from chronic myelogenous leukaemia (CML) cells [124]. Here, VCAM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.