Moreover, the familial hyperuricemia/gout observed in this study was not associated with a common variant, such as p.Q141K, but with a rare ABCG2 variant; this supports the recently proposed genetic concept, i.e., the “Common Disease, Multiple Common and Rare Variant” model [25,36], for the association between hyperuricemia/gout and the ABCG2 gene. This evidence concerns the gene ABCG2 and hyperuricemia.